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All five adults had growth hormone deficiency as children and received pituitary growth hormones prepared in a specific way from cadavers. The treatment approach was discontinued after cases of a rare brain disorder called Creutzfeldt-Jakob disease were found to be associated with the administration of contaminated human growth hormone from cadavers. Although Alzheimer’s is not a prion disease, some separate research suggests that the two proteins that are hallmarks in Alzheimer’s disease — amyloid beta and tau — behave like prions. “This study suggests that in very rare circumstances Alzheimer’s disease may be transmitted between humans via human growth hormone from deceased donors. “I’m also intrigued by how these results may inform potential therapeutic targets and strategies in the future,” Isaacson said, regarding Alzheimer’s disease.
Persons: John Collinge, Jakob, Creutzfeldt – Jakob, Alzheimer’s, ” Collinge, , , ” Dr, Susan Kohlhaas, ” Kohlhaas, “ It’s, Dr, Richard Isaacson, , Isaacson, “ I’m, ” Isaacson, , Gargi Banerjee, ” Banerjee, James Galvin, Sanjay Gupta, ” Galvin, Lewy Organizations: CNN, Nature, University College London Institute, University College London, National Hospital for Neurology, Neurosurgery, Alzheimer’s Research, Science Media, Comprehensive, Brain Health, University of Miami Health, CNN Health Locations: United Kingdom, United States, United, Florida, UHealth, Creutzfeldt
Times Insider explains who we are and what we do and delivers behind-the-scenes insights into how our journalism comes together. “It’s like a soap opera,” she said. “You start watching and you need to know what happens next week.”After John Collinge’s wife, Zandra, died last year, he felt compelled to share the news with the same group. The response, he said, “absolutely touched me and helped me through the sense of loss.”None of these widely scattered people — Mr. Pochiraju lives in Hyderabad, India; Ms. Cathcart, in Chapel Hill, N.C.; Ms. Robinson, outside Brisbane, Australia; and Mr. Collinge, in Bethesda, Md. They know one another through the online comments section of The New York Times’s Metropolitan Diary, a column that draws tens of thousands of readers each week.
Persons: Sivaram Pochiraju, Janet Cathcart, ” Lorie Robinson, , , John Collinge’s, Zandra, Pochiraju, Cathcart, Robinson, Collinge, Locations: , Hyderabad, India, Chapel Hill, N.C, Brisbane, Australia, Bethesda, Md, York Times’s
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